Jean Soulier’s team – Stem cell dysfunction and secondary AML

Clonal evolution in bone marrow failure syndrome as Fanconi anemia can result into ‘adaptive’ somatic genetic rescue, rescuing the HSC defect, or into ‘maladaptive’ evolution towards acute myeloid leukemia.

We profile patient samples at the single cell level and model bone marrow evolution using in vitro and mice experimental systems.

The adaptive or maladaptive deregulated pathways involve DNA damage response, inflammation, stem cell homeostasis and myeloid oncogenes.

Data inform on the BM dysfunction and pathway to sAML, with insights for patients staging and follow up.