A new institute

Intrinsic and extrinsic effects of the immune microenvironment in myelodysplastic syndromes

This project employs in vitro and ex vivo models to decipher how stromal and blast cells alter bone marrow NK cell-mediated immunosurveillance during MDS initiation and progression.

Nicolas Dulphy / Valéria Bisio

E-selectin antagonists in leukemia

Evaluation of molecules to block leukemia-microenvironment interaction and restore chemosensitivity.

Julien Calvo

Targeting the myeloid-specific isoform PIK3CG using heterobifunctional PROTAC-type degrader molecules to block AML progression.

Lois Kelly