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The pathologies treated
Acute Lymphoblastic Leukemias
Acute Myeloid Leukemias
Myeloproliferative Neoplasms
Myelodysplastic Syndromes
Leukemia Predisposition Syndromes
Acquired and Constitutional Bone Marrow Aplasias
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1stLeukemia Treatment and Research Center
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80Ongoing Clinical Trials
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Intrinsic and Extrinsic Effects of the Immune Microenvironment in Myelodysplastic Syndromes
This project employs in vitro and ex vivo models to decipher how stromal and blast cells alter bone marrow NK cell-mediated immunosurveillance during MDS initiation and progression.
E-selectin Antagonists in Leukemia
Evaluation of molecules to block leukemia-microenvironment interaction and restore chemosensitivity.
Targeting the myeloid-specific isoform PIK3CG using heterobifunctional PROTAC-type degrader molecules to block AML progression.
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