Necker Hospital – Department of Adult Hematology

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Olivier Hermine

Head of department

Stéphanie CHAMBAUD

Access and contact

Access and contact

Necker Hospital

149 rue de Sèvres

75015 Paris

Diseases managed

Multiple Myeloma

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia

Myelodysplastic Syndromes

Myeloproliferative Neoplasms

Lymphomas, including virus-associated lymphoma

Multiple Myeloma

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia

Myelodysplastic Syndromes

Myeloproliferative Neoplasms

Lymphomas, including virus-associated lymphoma

  • mastocytosis (CEREMAST),
  • hemoglobinopathies,
  • hereditary immunodeficiency disorders (CEREDIH),
  • Castleman disease (CRMdC),
  • lymphomas associated with celiac disease (CELAC),
  • inherited bleeding disorders (CRC),
  • adult autoimmune cytopenias (CeReCAI),
  • chronic neutropenias,
  • AL amyloidosis,
  • and other diseases caused by monoclonal immunoglobulin deposition.

Department activities

The department’s activities include outpatient consultations, pediatric-to-adult transition consultations, standard and intensive inpatient care, day hospital care, home-based care, and medical and paramedical teaching.

There is also a team of coordination nurses responsible for managing hospital–community links. They have developed a dedicated digital platform (currently INSTAMED) to ensure patient coordination and follow-up.

Advanced practice nurses are trained to provide specialized care for specific diseases, as well as to coordinate allogeneic transplantation, gene therapies, and cell therapies.

Patient Documentation

Multidisciplinary Team Meetings

This weekly multidisciplinary tumor board (MTB) is held under the supervision of Prof. F. Suarez at Necker and Prof. D. Bouscary at Cochin.

It is open to physicians from other public and private centers across both sites. Meetings are conducted in the presence of representatives from diagnostic laboratories (hematology, cytogenetics, immunology, and pathology) and sometimes radiologists and nuclear medicine specialists.

Decisions made during the MTB are based on jointly established guidelines between the two departments, as well as the available therapeutic options within academic or industry-sponsored clinical research protocols, which are regularly updated.

For some patients, the MTB serves to formally record established treatments, while for others it provides an opportunity to discuss complex cases.

For certain ‘personalized medicine’ cases, a dedicated MTB may be requested with the laboratories, drawing on the myeloid molecular MTB (Prof. O. Kosmider and Dr. J. Ducrocq) and the lymphoid molecular MTB (Dr. L. Lhermitte and Prof. V. Asnafi).

Weekly

A dedicated committee for CAR-T cell therapy indications is in place, involving the cell therapy department, pharmacists, referring physicians, and coordinators from both sites, with information shared with the intensive care units.

This tumor board is linked to the allogeneic transplantation committee, which meets separately from the multidisciplinary boards and determines indications for transplantation and CAR-T therapy.

Twice Monthly

A meeting is held with the onco-geriatric specialists every two weeks with Dr. Cécile Bally, Dr. Clarisse Cazelles, and Dr. Clémence Loiseau.

See the tumor boards for rare diseases within the national reference centers (Adult hereditary immunodeficiencies – monthly, CELAC – monthly, Mastocytosis – monthly):

In addition, as both departments coordinate several national reference centers, national tumor boards are organized and led by physicians from both services for:

• adult hereditary immunodeficiencies (F. Suarez, M. Cheminant, D. Boutboul),
• Castleman disease (D. Boutboul),
• Mastocytosis (J. Rossignol and O. Hermine),
• lymphoproliferative disorders associated with celiac disease (M. Cheminant, C. Loiseau, and O. Hermine),
• NKT lymphomas (O. Hermine).

When necessary for patient management, some physicians from the department also participate in other national tumor boards (sickle cell disease, aplastic anemia, neutropenias, myeloproliferative neoplasms, cerebral and ocular lymphomas, etc.)

Twice Monthly

At both the Necker and Cochin sites, a bi-monthly hemostasis tumor board is organized (Drs. C. Bally and L. Frenzel at Necker, and Prof. M. Fontenay at Cochin) together with the hemostasis laboratories from both sites.

Our clinical trials

Numerous clinical trials are currently open in the department.

As an example, a few trials are presented below:

Phase 3, multicenter, open-label, controlled, parallel-group study designed to evaluate the safety and efficacy of elranatamab in combination with lenalidomide following D-VRd induction, compared with standard treatment after induction followed by autologous stem cell transplantation, D-VRd consolidation, and lenalidomide maintenance in patients with newly diagnosed multiple myeloma eligible for transplantation.

Randomized, non-comparative Phase II study of Lacutamab + GEMOX versus GEMOX alone in patients with relapsed/refractory peripheral T-cell lymphoma

Multicenter, randomized Phase II study: CPX-351 versus intensive chemotherapy in patients with de novo AML at intermediate or adverse risk, stratified according to their genomic profile.

Randomized, double-blind, placebo-controlled Phase 2/3 study of BLU-263 in indolent systemic mastocytosis.

Multicenter, open-label, randomized Phase 2 study comparing elranatamab plus lenalidomide versus daratumumab plus lenalidomide as post-transplant maintenance therapy in patients with newly diagnosed multiple myeloma

Open-label, controlled, randomized, multicenter, international study evaluating the benefit of autologous stem cell transplantation after first-line complete response in patients with T-cell lymphoma.

Phase 2 study of the Gemtuzumab Ozogamicin (GO) – Gilteritinib combination in adults with relapsed/refractory (R/R) acute myeloid leukemia (AML) harboring FLT3-ITD and/or FLT3-TKD mutations.

Phase 2, open-label, randomized study evaluating elenestinib (BLU-263) as monotherapy or in combination therapy in indolent systemic mastocytosis.

Team members

Olivier Hermine
University Professor, Hospital Practitioner
Felipe Suarez
University Professor, Hospital Practitioner
Morgane Cheminant
University Professor, Hospital Practitioner
Cécile Bally
Hospital Practitioner
Clarisse Cazelle
Hospital Practitioner
Laurent Frenzel
Hospital Practitioner
Clémence Loiseau
Hospital Practitioner
Stéphanie Cordeil
Contractual Hospital Practitioner
Margaux Garzarro
Contractual Hospital Practitioner
Tony Huynh
Contractual Hospital Practitioner
Valérie Quevreux
Senior Manager of DMU
Cécile Deroux-Dauphin
Senior Manager (affiliated with Necker and Cochin)
Christophe Vairon
Manager
Maiwen Rivoal
Manager
Ariane Leguay
Psychologist
Laurence Boismaigre
Social Worker
Rafik Bouali
Coordinator
Yohan Demay
Clinical Research Associate
Nawel Zegrour
Clinical Research Associate
Khadidja Lebeche
Clinical Research Associate
Rana El Masri
Clinical Research Associate
Stéphanie Agbolo
Clinical Research Nurse