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Accueil » Patient care » Necker Hospital – Department of Adult HematologyNecker Hospital – Department of Adult Hematology
...Olivier Hermine
Head of department
Access and contact
Necker Hospital
149 rue de Sèvres
75015 Paris
Diseases managed
Multiple Myeloma
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Myelodysplastic Syndromes
Myeloproliferative Neoplasms
Lymphomas, including virus-associated lymphoma
Multiple Myeloma
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Myelodysplastic Syndromes
Myeloproliferative Neoplasms
Lymphomas, including virus-associated lymphoma
- mastocytosis (CEREMAST),
- hemoglobinopathies,
- hereditary immunodeficiency disorders (CEREDIH),
- Castleman disease (CRMdC),
- lymphomas associated with celiac disease (CELAC),
- inherited bleeding disorders (CRC),
- adult autoimmune cytopenias (CeReCAI),
- chronic neutropenias,
- AL amyloidosis,
- and other diseases caused by monoclonal immunoglobulin deposition.
Department activities
The department’s activities include outpatient consultations, pediatric-to-adult transition consultations, standard and intensive inpatient care, day hospital care, home-based care, and medical and paramedical teaching.
There is also a team of coordination nurses responsible for managing hospital–community links. They have developed a dedicated digital platform (currently INSTAMED) to ensure patient coordination and follow-up.
Advanced practice nurses are trained to provide specialized care for specific diseases, as well as to coordinate allogeneic transplantation, gene therapies, and cell therapies.
Multidisciplinary Team Meetings
This weekly multidisciplinary tumor board (MTB) is held under the supervision of Prof. F. Suarez at Necker and Prof. D. Bouscary at Cochin.
It is open to physicians from other public and private centers across both sites. Meetings are conducted in the presence of representatives from diagnostic laboratories (hematology, cytogenetics, immunology, and pathology) and sometimes radiologists and nuclear medicine specialists.
Decisions made during the MTB are based on jointly established guidelines between the two departments, as well as the available therapeutic options within academic or industry-sponsored clinical research protocols, which are regularly updated.
For some patients, the MTB serves to formally record established treatments, while for others it provides an opportunity to discuss complex cases.
For certain ‘personalized medicine’ cases, a dedicated MTB may be requested with the laboratories, drawing on the myeloid molecular MTB (Prof. O. Kosmider and Dr. J. Ducrocq) and the lymphoid molecular MTB (Dr. L. Lhermitte and Prof. V. Asnafi).
Weekly
A dedicated committee for CAR-T cell therapy indications is in place, involving the cell therapy department, pharmacists, referring physicians, and coordinators from both sites, with information shared with the intensive care units.
This tumor board is linked to the allogeneic transplantation committee, which meets separately from the multidisciplinary boards and determines indications for transplantation and CAR-T therapy.
Twice Monthly
A meeting is held with the onco-geriatric specialists every two weeks with Dr. Cécile Bally, Dr. Clarisse Cazelles, and Dr. Clémence Loiseau.
See the tumor boards for rare diseases within the national reference centers (Adult hereditary immunodeficiencies – monthly, CELAC – monthly, Mastocytosis – monthly):
In addition, as both departments coordinate several national reference centers, national tumor boards are organized and led by physicians from both services for:
• adult hereditary immunodeficiencies (F. Suarez, M. Cheminant, D. Boutboul),
• Castleman disease (D. Boutboul),
• Mastocytosis (J. Rossignol and O. Hermine),
• lymphoproliferative disorders associated with celiac disease (M. Cheminant, C. Loiseau, and O. Hermine),
• NKT lymphomas (O. Hermine).When necessary for patient management, some physicians from the department also participate in other national tumor boards (sickle cell disease, aplastic anemia, neutropenias, myeloproliferative neoplasms, cerebral and ocular lymphomas, etc.)
Twice Monthly
At both the Necker and Cochin sites, a bi-monthly hemostasis tumor board is organized (Drs. C. Bally and L. Frenzel at Necker, and Prof. M. Fontenay at Cochin) together with the hemostasis laboratories from both sites.
Our clinical trials
Numerous clinical trials are currently open in the department.
As an example, a few trials are presented below:
Phase 3, multicenter, open-label, controlled, parallel-group study designed to evaluate the safety and efficacy of elranatamab in combination with lenalidomide following D-VRd induction, compared with standard treatment after induction followed by autologous stem cell transplantation, D-VRd consolidation, and lenalidomide maintenance in patients with newly diagnosed multiple myeloma eligible for transplantation.
Randomized, non-comparative Phase II study of Lacutamab + GEMOX versus GEMOX alone in patients with relapsed/refractory peripheral T-cell lymphoma
Multicenter, randomized Phase II study: CPX-351 versus intensive chemotherapy in patients with de novo AML at intermediate or adverse risk, stratified according to their genomic profile.
Randomized, double-blind, placebo-controlled Phase 2/3 study of BLU-263 in indolent systemic mastocytosis.
Multicenter, open-label, randomized Phase 2 study comparing elranatamab plus lenalidomide versus daratumumab plus lenalidomide as post-transplant maintenance therapy in patients with newly diagnosed multiple myeloma
Open-label, controlled, randomized, multicenter, international study evaluating the benefit of autologous stem cell transplantation after first-line complete response in patients with T-cell lymphoma.
Phase 2 study of the Gemtuzumab Ozogamicin (GO) – Gilteritinib combination in adults with relapsed/refractory (R/R) acute myeloid leukemia (AML) harboring FLT3-ITD and/or FLT3-TKD mutations.
Phase 2, open-label, randomized study evaluating elenestinib (BLU-263) as monotherapy or in combination therapy in indolent systemic mastocytosis.
Team members
Olivier HermineUniversity Professor, Hospital PractitionerFelipe SuarezUniversity Professor, Hospital PractitionerMorgane CheminantUniversity Professor, Hospital PractitionerCécile BallyHospital PractitionerClarisse CazelleHospital PractitionerLaurent FrenzelHospital PractitionerClémence LoiseauHospital PractitionerStéphanie CordeilContractual Hospital PractitionerMargaux GarzarroContractual Hospital PractitionerTony HuynhContractual Hospital PractitionerValérie QuevreuxSenior Manager of DMUCécile Deroux-DauphinSenior Manager (affiliated with Necker and Cochin)Christophe VaironManagerMaiwen RivoalManagerAriane LeguayPsychologistLaurence BoismaigreSocial WorkerRafik BoualiCoordinatorYohan DemayClinical Research AssociateNawel ZegrourClinical Research AssociateKhadidja LebecheClinical Research AssociateRana El MasriClinical Research AssociateStéphanie AgboloClinical Research NurseStay up to date by subscribing to the institute's newsletter
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