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Department of Pharmacology and Clinical Investigations
Vincent LEVY
Head of Department
Access and contact
Saint-Louis Hospital
1 avenue Claude Vellefaux
75475 PARIS Cedex 10
Diseases managed
Malignant hematologic diseases
Oncodermatology
Department activities
This strategic focus aims to develop innovative treatments in our core areas of expertise, with priority on:
- Malignant hematologic diseases
- Oncodermatology
In these fields, CIC-1427 has participated in numerous very early-phase clinical trials in recent years, several of which have led to major advances:
- Significant improvement in survival and quality of life for patients with myeloproliferative neoplasms, leukemias, myelodysplastic syndromes, and melanoma.
Beyond these specialties, CIC-1427 also contributes to early trials in other tumor types, based on its members’ expertise:
- Digestive tumors
- Lung tumors
- Breast cancer
- Urological cancers
CIC-1427 also provides support for organizing activities related to clinical research and is committed to implementing a quality management approach tailored to our structure, ensuring participant safety through functional organization and rigorous procedures.
The Saint-Louis CLIP² is ISO 9001:2015 certified by AFNOR since 2021. This certification covers the quality management system for all clinical investigation activities (from feasibility to study closure and archiving).
The dedicated CIC-1427 staff, trained in clinical trials, Good Clinical Practice (GCP), and current regulations, includes:
Medical staff :1 Head of Department, 5 Physicians (1 Full Professor, 2 Associate Professors, 1 Senior Physician, 1 Assistant Physician)
Non-medical staff: 1 head nurse, 7 nurses, 2 nursing sssistants, 1 secretary
Research Staff: 1 Project Manager, 3 Clinical Research Associates
Patient information
Ensuring effective patient pathway management is a key quality objective to guarantee the smooth conduct of clinical trials and participant safety.
Patient Pathway Objectives:
- Provide volunteers with a clear overview of the standard process, while considering protocol-specific requirements.
- Serve as a reference for healthcare professionals involved in clinical research.
Clinical trials
Myelofibrosis not previously treated with a JAK inhibitor, with splenomegaly.
Ruxolitinib-intolerant or -refractory myelofibrosis with splenomegaly.
Myelofibrosis previously treated with a JAK inhibitor and presenting intolerance, resistance, refractoriness, or loss of response to the JAK inhibitor, or ineligible for treatment with ruxolitinib or fedratinib.
JAK inhibitor–intolerant, resistant, or ineligible myelofibrosis with CALR gene mutations.
Essential thrombocythemia, intolerant, resistant, or refractory to hydroxyurea (HU), with gene mutations.
High-risk JAK2-mutated essential thrombocythemia or polycythemia vera, without thrombotic events since diagnosis.
High-risk polycythemia vera.
JAK inhibitor–naïve myelofibrosis with moderate thrombocytopenia.
Thrombocytopenic myelofibrosis with splenomegaly.
Myeloproliferative neoplasms with CALR mutation.
Essential thrombocythemia, treatment-naïve to cytoreductive therapy.
Essential thrombocythemia with inadequate response or intolerance to hydroxyurea.
High-risk polycythemia vera – first-line treatment.
Team members
Pr Vincent LEVYHead of DepartmentPr Jean-Jacques KILADJIANFull ProfessorDr Lina BENAJIBAAssociate ProfessorDr Heriberto BRUZZONI-GIOVANELLIAssociate ProfessorDr Juliette SORET-DULPHYSenior PhysicianDr Rafael DALTRO DE OLIVEIRAAssistant PhysicianCISSE TenneHead NurseCHEDDAD SamiaNurseDOS REIS MADEIRA AdrianaNurseGARCON SophieNurseMAOU RabiaaNursePINTOR YoannNursePOUSADA PIDRE SaletaNurseRODRIGUES CécileNurseSARANE MargueriteNurseCEROL Marie aimeeNursing AssistantMONLOUIS CécileNursing AssistantTROUDI AzizaSecretaryALLAOUA SouhilProject ManagerJin HUANGClinical Research Associates (CRA/Study Coordinators)Nabil ABDELJALILClinical Research Associates (CRA/Study Coordinators)ZHENG DazhongClinical Research Associates (CRA/Study Coordinators)Join our team
Would you like to contribute to clinical research and participate in innovative projects within a multidisciplinary and dynamic environment?
The Clinical Investigation Center (CIC) at Saint-Louis Hospital regularly recruits motivated professionals to strengthen its teams.
Discover our opportunities and apply now by clicking the link below:
- Our technological platforms
- Our clinical services
- Discover the Leukemia Institute
- Translational research
- Our clinical research
- Clinical trials
- Become an expert patient
- To be cared for and supported
- Our news
- A new Institute dedicated to combating Leukemia
