Profile of Julien Calvo, researcher in the “Niche, Cancer, and Radiation in Hematopoiesis” team led by Françoise Pflumio
His background
Julien Calvo began his career as a technician in the neuro-virology department before joining the Hematopoietic Stem Cells and Leukemia Research Laboratory.
He developed a unique in vitro co-culture model to evaluate the multipotent potential of human hematopoietic stem/progenitor cells [Calvo et al., PLOS One, 2012].
He resumed his studies and completed his Ph.D. at the ED HOB of the University of Paris Cité, focusing on pediatric T-cell acute lymphoblastic leukemia (T-ALL). He became a researcher at the CEA in October 2019.
He is now investigating how T-ALL leukemic cells are “educated” by various components of the bone marrow, including adipocytes [Cahu & Calvo et al., Blood Adv, 2017; Calvo et al., Leukemia, 2025].
His scientific publications
Assessment of Human Multi-Potent Hematopoietic Stem/Progenitor Cell Potential Using a Single In Vitro Screening System
Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia
High CD44 expression and enhanced E-selectin binding identified as biomarkers of chemoresistant leukemic cells in human T-ALL
His research focus areas
How does bone marrow adipose tissue communicate with T-ALL cells, and how might it compromise therapeutic response?
What are the interactions between non-hematopoietic cells in the bone marrow and T-ALL cells?
Identify leukemic vulnerabilities linked to the bone marrow microenvironment to develop new targeted therapies.