Accueil Karl Balabanian’s team – Lymphoid niches, Chemokines and Immuno-hematological syndromes

Karl Balabanian’s team – Lymphoid niches, Chemokines and Immuno-hematological syndromes

Karl Balabanian

Team leader

Marion Espéli

Deputy Team Leader

Institut de recherche Saint-Louis

Courriel

Research themes

Our strategy aims to delineate molecular & cellular aspects of the cross-talk established between lymphoid and stromal cells within the bone marrow, skin & thymus with a focus on the chemokine signaling system to better understand and fight immuno-hematological disorders including the WHIM Syndrome, MyeloDysplastic Syndromes and T-cell acute lymphoblastic leukemia.

Studied pathologies

MyeloDysplastic Syndromes

Secondary acute myeloid leukemia

WHIM Syndrome

Waldenström’s Macroglobulinemia

T-cell acute lymphoblastic leukemia

Sezary Syndrome

MyeloDysplastic Syndromes

Secondary acute myeloid leukemia

WHIM Syndrome

Waldenström’s Macroglobulinemia

T-cell acute lymphoblastic leukemia

Sezary Syndrome

Research areas

Axis 1

Understanding the dialogue between lymphoid cells and their microenvironment

Axis 2

Deciphering the role of adaptive and innate lymphocytes in malignant microenvironments

Featured research projects

Impact of nutrient sensing and metabolic rewiring on genomic integrity in early and activated lymphoid cells

This project investigates how CXCR4 signaling shapes the spatial and metabolic landscape of hematopoietic progenitors and plasma cells and how this impacts their fate and genomic integrity.

K. Balabanian / M. Espéli

Intrinsic and extrinsic effects of the immune microenvironment in myelodysplastic syndromes

This project employs in vitro and ex vivo models to decipher how stromal and blast cells alter bone marrow NK cell-mediated immunosurveillance during MDS initiation and progression.

Nicolas Dulphy / Valéria Bisio

Unraveling the Immune Impact of Clonal Hematopoiesis and Myelodysplastic Syndromes Through Their Interaction with Immune-Mediated Inflammatory Disorders

This project investigates interactions between clonal hematopoiesis (CH), MDS and immune-mediated inflammatory disorders through large-scale epidemiologic studies, murine arthritis models, and multiomics analyses to elucidate the impact of CH on immune dysregulation.

L.P. Zhao

Karl Balabanian's team members

BALABANIAN Karl	DR2 INSERM, HDR, team leader, deputy head of the Institute
ESPÉLI Marion	DR2 INSERM, HDR, deputy team leader
BENLAGHA Kamel	DR2 INSERM, HDR
BISIO Valeria	CRCN INSERM (HDR pending)
MOINS Hélène	PUPH Univ. Paris Cité, AP-HP, HDR
TOUBERT Antoine	PUPH Univ. Paris Cité, AP-HP, HDR
DULPHY Nicolas	MCU-PH Univ. Paris Cité, AP-HP, HDR
ZHAO Lin-Pierre	PH APHP (HDR pending)
REA Delphine	PH AP-HP
CLAVÉ Emmanuel	IR Univ. Paris Cité, HDR
LERECLUS Émilie	IE DRCI CDI
KERGARAVAT Camille	IE UPCité, PhD student Univ. Paris Cité
GOURHAND Vanessa	AI INSERM
ROSINEL Patricia	Research Technician BAP J INSERM
OULD-CHIKH Zohra	AJT INSERM
KALOGERAKI Maria	PhD student Univ. Paris Cité
CHENG Jun-Ting	PhD student Univ. Paris Cité
GODARD Clarisse	PhD student Univ. Paris Cité
M’SIBIH Inès	PhD student Univ. Paris Cité
MELHEM Houda	PhD student Univ. Paris Cité
TA Van Anh	PhD student Univ. Paris Cité
DEBUREAUX Pierre-Edouard	PhD student Univ. Paris Cité, ITMO Cancer/FRFT
MOULIN Clémentine	PhD student Univ. Paris Cité, poste d’accueil INSERM
CASTILLO SILVA Flore Elena	M2 student Univ. Paris Cité
FEDERICI Andrea	M2 student Univ. Paris Cité
LI Andy	M2 student Univ. Paris Cité
MOUGAMMADOU Shaïna	M2 student Univ. Paris Cité