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Lymphoid niches, Chemokines and Immuno-hematological syndromes
Karl Balabanian
Team leader
Marion Espéli
Deputy Team Leader
Research themes
Our strategy aims to delineate molecular & cellular aspects of the cross-talk established between lymphoid and stromal cells within the bone marrow, skin & thymus with a focus on the chemokine signaling system to better understand and fight immuno-hematological disorders including the WHIM Syndrome, MyeloDysplastic Syndromes and T-cell acute lymphoblastic leukemia.
Studied pathologies
MyeloDysplastic Syndromes
Secondary acute myeloid leukemia
WHIM Syndrome
Waldenström’s Macroglobulinemia
T-cell acute lymphoblastic leukemia
Sezary Syndrome
Research areas
Understanding the dialogue between lymphoid cells and their microenvironment
Deciphering the role of adaptive and innate lymphocytes in malignant microenvironments
Featured research projects
Impact of nutrient sensing and metabolic rewiring on genomic integrity in early and activated lymphoid cells
This project investigates how CXCR4 signaling shapes the spatial and metabolic landscape of hematopoietic progenitors and plasma cells and how this impacts their fate and genomic integrity.
Intrinsic and Extrinsic Effects of the Immune Microenvironment in Myelodysplastic Syndromes
This project employs in vitro and ex vivo models to decipher how stromal and blast cells alter bone marrow NK cell-mediated immunosurveillance during MDS initiation and progression.
Unraveling the Immune Impact of Clonal Hematopoiesis and Myelodysplastic Syndromes Through Their Interaction with Immune-Mediated Inflammatory Disorders
This project investigates interactions between clonal hematopoiesis (CH), MDS and immune-mediated inflammatory disorders through large-scale epidemiologic studies, murine arthritis models, and multiomics analyses to elucidate the impact of CH on immune dysregulation.
Team members
BALABANIAN KarlDR2 INSERM, HDR, team leader, deputy head of the InstituteESPÉLI MarionDR2 INSERM, HDR, deputy team leaderBENLAGHA KamelDR2 INSERM, HDRBISIO ValeriaCRCN INSERM (HDR pending)MOINS HélènePUPH Univ. Paris Cité, AP-HP, HDRTOUBERT AntoinePUPH Univ. Paris Cité, AP-HP, HDRDULPHY NicolasMCU-PH Univ. Paris Cité, AP-HP, HDRZHAO Lin-PierrePH APHP (HDR pending)REA DelphinePH AP-HPCLAVÉ EmmanuelIR Univ. Paris Cité, HDRLERECLUS ÉmilieIE DRCI CDIKERGARAVAT CamilleIE UPCité, PhD student Univ. Paris CitéGOURHAND VanessaAI INSERMROSINEL PatriciaResearch Technician BAP J INSERMOULD-CHIKH ZohraAJT INSERMKALOGERAKI MariaPhD student Univ. Paris CitéCHENG Jun-TingPhD student Univ. Paris CitéGODARD ClarissePhD student Univ. Paris CitéM’SIBIH InèsPhD student Univ. Paris CitéMELHEM HoudaPhD student Univ. Paris CitéTA Van AnhPhD student Univ. Paris CitéDEBUREAUX Pierre-EdouardPhD student Univ. Paris Cité, ITMO Cancer/FRFTMOULIN ClémentinePhD student Univ. Paris Cité, poste d’accueil INSERMCASTILLO SILVA Flore ElenaM2 student Univ. Paris CitéFEDERICI AndreaM2 student Univ. Paris CitéLI AndyM2 student Univ. Paris CitéMOUGAMMADOU ShaïnaM2 student Univ. Paris CitéScientific publications
Hematologic disorder-associated Cxcr4 gain-of-function mutation leads to uncontrolled extrafollicular immune response
Alouche N & al, Blood. 2021Lire la publication
Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Boy M & al, Nat Commun. 2023Lire la publication
CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism
Rondeau V & al, Sci Signal, 2024Lire la publicationFunding
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