Accueil Stéphane Giraudier’s team – Chronic Myeloid Malignancies, Microenvironment & Translational Research

Stéphane Giraudier’s team – Chronic Myeloid Malignancies, Microenvironment & Translational Research

Stéphane Giraudier

Team leader

Institut de recherche Saint-Louis

Research themes

Our team develops translational models to improve the understanding and treatment of Myeloproliferative Neoplasms (MPNs): patient samples, patient-derived cell lines, induced pluripotent stem cells (iPSCs), murine models (transgenic and transplantable), primary cell cultures, next-generation sequencing, lentiviral transduction, cell sorting, and microfluidic-based single-cell DNA analysis. Ongoing projects focus on modeling normal and JAK2V617F-mutated stress hematopoiesis, exploring the bone marrow microenvironment in MPN patients, and studying how clonal selection impacts clinical outcome and therapy response.

Research areas

Microenvironment and Evolution

We study the impact of the bone marrow niche in MPNs, particularly its role in regulating mutated hematopoiesis and contributing to treatment resistance.

Clonal Evolution of MPNs

We investigate clonal dynamics in MPNs under therapeutic pressure and stress conditions, aiming to understand how aggressive subclones emerge and expand.

Featured research projects

Microenvironmental role in MPN progression

Deciphering stromal-tumor interactions and their contribution to disease evolution and therapeutic escape.

Bruno Cassinat & Laura Velazquez

Interferon response and immunity in MPNs

In vitro and in vivo modeling of IFNα response in JAK2V617F context and investigation of immune-mediated therapeutic mechanisms.

Stéphane Giraudier

Clonal selection under therapy

Monitoring clonal evolution in treated patients and exploring senescence and senolysis as therapeutic targets in MPNs.

Nabih Maslah & Jean-Jacques Kiladjian

Stéphane Giraudier's team members

Stéphane Giraudier	Team Leader, Full Professor (PU-PH)
Jean-Jacques Kiladjian	Full Professor (PU-PH)
Bruno Cassinat	Hospital Practitioner (PH)
Pierre Fenaux	Full Professor (PU-PH)
Nabih Maslah	Associate Professor (MCU-PH)
Sarah Awan-Toor	Research Engineer
Laura Velazquez	Research Scientist (CR1)
Bochra Mlayah	Research Assistant
Emmanuelle Verger	Research Engineer
Liu Duanya	PhD Student
Pierre Painsec	Research Assistant
Diego Elrio	Assistant Hospital-University Practitioner (AHU)
Jimena Castorena	Research Engineer
Nelly Bosselut	PH
Louis Drevon	PH