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Chronic Myeloid Malignancies, Microenvironment & Translational Research
Stéphane Giraudier
Team leader
Research themes
Our team develops translational models to improve the understanding and treatment of Myeloproliferative Neoplasms (MPNs): patient samples, patient-derived cell lines, induced pluripotent stem cells (iPSCs), murine models (transgenic and transplantable), primary cell cultures, next-generation sequencing, lentiviral transduction, cell sorting, and microfluidic-based single-cell DNA analysis. Ongoing projects focus on modeling normal and JAK2V617F-mutated stress hematopoiesis, exploring the bone marrow microenvironment in MPN patients, and studying how clonal selection impacts clinical outcome and therapy response.
Research areas
We study the impact of the bone marrow niche in MPNs, particularly its role in regulating mutated hematopoiesis and contributing to treatment resistance.
We investigate clonal dynamics in MPNs under therapeutic pressure and stress conditions, aiming to understand how aggressive subclones emerge and expand.
Featured research projects
Microenvironmental role in MPN progression
Deciphering stromal-tumor interactions and their contribution to disease evolution and therapeutic escape.
Interferon response and immunity in MPNs
In vitro and in vivo modeling of IFNα response in JAK2V617F context and investigation of immune-mediated therapeutic mechanisms.
Clonal selection under therapy
Monitoring clonal evolution in treated patients and exploring senescence and senolysis as therapeutic targets in MPNs.
Team members
Stéphane GiraudierTeam Leader, Full Professor (PU-PH)Jean-Jacques KiladjianFull Professor (PU-PH)Bruno CassinatHospital Practitioner (PH)Pierre FenauxFull Professor (PU-PH)Nabih MaslahAssociate Professor (MCU-PH)Sarah Awan-ToorResearch EngineerLaura VelazquezResearch Scientist (CR1)Bochra MlayahResearch AssistantEmmanuelle VergerResearch EngineerLiu DuanyaPhD StudentPierre PainsecResearch AssistantDiego ElrioAssistant Hospital-University Practitioner (AHU)Jimena CastorenaResearch EngineerNelly BosselutPHLouis DrevonPHScientific publications
JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms
Nabih Maslah & al, Nat Commun., 2025Lire la publication
Comprehensive analysis of mesenchymal cells reveals a dysregulated TGF-β/WNT/HOXB7 axis in patients with myelofibrosis
Ganesan & al, JCI Insight, 2024Lire la publication
Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms
Gou & al, Blood Cancer J, 2024Lire la publicationFunding
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