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Hematology Medical Laboratory, Jean Soulier
Jean Soulier
Saint-Louis Hospital
1 Av Claude Vellefaux
75010 Paris
Diseases
Acute and chronic leukemia
Myelodysplastic syndromes
Bone marrow failure syndromes
Myeloproliferative neoplasia
Genetic predisposition to MDS and leukemia
Department activities
Biological diagnosis and follow up for patients with benign and malignant hematology from Saint-Louis hospital and from clinical networks and trials in France.
Biobanking of tumoral and germline samples from the cohorts.
Multidisciplinary Team Meetings
National tumor board for acute leukemia (PRECILA)
Referent for biology Pr Emmanuelle Clappier
National board for aplasia (RIME)
Referents for biology Pr Jean Soulier, Dr Lise Larcher
National board for leukemia predisposition
Referents for biology Pr Emmanuelle Clappier, Dr Lise Larcher
Team members
Emmanuelle ClappierPU-PHHélène MoinsPU-PHJean-Michel CayuelaMCU-PHRathana KimMCU-PHWendy CuccuiniPHLise LarcherPHPierre LemairePHOdile MaarekPHStéphanie MathisPHMarie PassetPHLaureen ChatAHUMatthieu DuchmannAHUMélanie Da CostaINGWilliam PlasINGJulie RenardINGNadia VasquezING - Our technological platforms
- Our clinical services
- Discover the Leukemia Institute
- Translational research
- Our clinical research
- Clinical trials
- Become an expert patient
- To be cared for and supported
- Our news
- A new Institute dedicated to combating Leukemia
Featured research projects
Adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) are complex and heterozygous entities at both the genomic and prognosis levels. In the frame of the GRAALL network (Group for research in Adult Acute Lymphoblastic Leukemia), the hospital/university/Inserm team profiles the genomic landscape and biological features of BCP-ALL, studies oncogenic mechanisms and develop preclinical models to yield precision medicine.
Emmanuelle Clappier, Rathana Kim and Marie Passet
Bone marrow clonal evolution in Fanconi anemia can result into ‘adaptive’ somatic genetic rescue, rescuing the HSCP defect, or into ‘maladaptive’ evolution towards acute myeloid leukemia. We profile patient samples at the single cell level and model bone marrow evolution using in vitro and mice experimental systems. The adaptive or maladaptive deregulated pathways involve DNA damage response, inflammation, stem cell homeostasis and myeloid oncogenes. Data are relevant with various inherited or acquired BM dysfunction and clonal adaptation that may lead to secondary leukemia.
Jean Soulier, Lise Larcher